Allessan CAP: The versatile and cost saving coupling reagent

Due to its outstanding properties, it is safe to handle and easy to store. Additionally, using Allessan^® CAP will lower your overall process costs, compared to staying with the standard protocol, applying DCC/ HOBt.

Use of coupling reagents for converting carboxylic acids is nowadays widely spread. Specialized coupling reagents, enabling direct condensation of a carboxylic acid moiety and an alcohol or amine, offer a superior direct approach towards highly valuable carboxylic acid derivatives. Among these coupling reagents, Allessan^® CAP offers a wide range of benefits.

Apart from its long shelf life (36 months), its high thermal stability (up to 300°C) and its excellent safety profile (no CMR-properties associated), Allessan^® CAP proves to be the no. 1 alternative to coupling reagents such as DCC/HOBt, EDC, or CDI.

Being produced in Germany in an ISO9001 & ISO14001 certified facility for more than one decade, no supply chain interruptions due to tightened environmental regulations are to be expected, giving peace of mind to any procurement/supply chain associate.

Besides its outstanding properties, Allessan^® CAP offers serious cost savings switching to an alternative protocol (figure 2). This is the case for example for the synthesis of active pharmaceutical ingredients (APIs) using Allessan^® CAP (see figure 3).

Possible uses of Allessan^® CAP include amidations, esterifications, Swern-type oxidations as substitute for oxalyl dichloride, and as catalyst during Aza-Diels-Adler reactions.

For more information please contact us via intermediates@weylchem.com.