26.11.2025 • News

AstraZeneca to Invest $2 Billion in US Biologics Facility

Fourth major US manufacturing investment announced this year, advancing AstraZeneca’s historic $50 billion commitment to medicines manufacturing and R&D. New capacity at AstraZeneca’s Frederick and Gaithersburg facilities will accelerate production of cancer, rare, and chronic disease medicines

AstraZeneca Facility, Gaithersburg, USA.
AstraZeneca Facility, Gaithersburg, USA.
© AstraZeneca

AstraZeneca recently announced plans to invest $2 billion to expand its long-standing manufacturing footprint in Maryland. This includes a significant expansion of its flagship biologics manufacturing facility in Frederick and construction of a new state-of-the-art facility in Gaithersburg for the development and clinical supply of innovative molecules to be used in clinical trials. The investment will support 2,600 jobs across the two sites in the state, including the retention of local roles, construction activity, and the creation of 300 highly skilled jobs.

The Frederick facility currently produces biologics, a type of medication used across AstraZeneca’s portfolio of cancer, autoimmune, respiratory, and rare disease treatments. The planned expansion will nearly double commercial manufacturing capacity, enabling increased supply of existing medicines and, for the first time, production across the Company’s rare disease portfolio. In parallel, AstraZeneca will build a new clinical manufacturing facility to expand its footprint in Gaithersburg.  

Both the expanded facility in Frederick and the new facility in Gaithersburg will leverage cutting-edge AI, automation, and data analytics, and be built to the highest environmental standards.

Pascal Soriot, Chief Executive Officer, AstraZeneca, said: “Today marks a landmark moment for Maryland and American patients. As the state’s largest biopharmaceutical employer, we are deepening our long-standing commitment to Maryland – supporting 2,600 jobs, catalyzing economic growth, and bringing our extensive rare disease portfolio onshore for the first time. This investment strengthens the resilience of the US medicines supply chain and accelerates access to transformative therapies for patients across America and around the world.”

The announcement is part of AstraZeneca’s $50 billion investment announced in July. It follows a series of US commitments over the past six months, including unveiling a new cell therapy manufacturing facility in Rockville, Maryland, a new drug substance manufacturing facility in Virginia, and the expansion of the Company’s existing manufacturing facility in Coppell, Texas. The US is AstraZeneca’s largest market by sales and is also home to 19 R&D, manufacturing, and commercial sites. 

Company

Logo:

AstraZeneca

Byggrad 2/4
15185 Södertälje
Sweden

Company contact







Virtual Event

Downstream Purification
Bioprocess Forum

Downstream Purification

Save the Date: November 21+25, 2025
Join leading scientists, process engineers, and biomanufacturing innovators for a two-day virtual event exploring the latest breakthroughs in downstream purification.

Free Expert Insights

Dual‑Targeting Breakthroughs
Advancements in Bispecific Antibody Development

Dual‑Targeting Breakthroughs

Unlock the latest breakthroughs in bispecific antibody development! Download Wiley’s free Expert Insights eBook to explore cutting-edge dual-targeting strategies, advanced purification methods, and bioanalytical technologies transforming immunotherapy and cancer treatment.

most read

Photo

VCI Welcomes US-EU Customs Deal

The German Chemical Industry Association (VCI) welcomes the fact that Ursula von der Leyen, President of the European Commission, and US President Donald Trump have averted the danger of a trade war for the time being.