16.05.2017 • NewsElaine BurridgePfizerR&D

Pfizer and Sangamo Link on Hemophilia A

(c) anyaivanova/Shutterstock
(c) anyaivanova/Shutterstock

Major US drugmaker Pfizer is collaborating with Sangamo Therapeutics to develop and commercialize gene therapy programs for the rare blood disorder hemophilia A. The agreement includes SB-525, one of Sangamo’s four lead product candidates.

The US Food and Drug Administration has cleared initiation of human clinical trials for SB-525, which has been granted orphan drug status.

Under the terms of the deal, Sangamo will receive an upfront payment of $70 million from Pfizer as well as potential milestone payments of up to $475 million, including up to $300 million for the development and commercialization of SB-525 and up to $175 million for additional candidate drugs developed under the partnership. The California-based biotech will also receive tiered double-digit royalties on net sales.

Sangamo will conduct the SB-525 Phase I/II clinical study and certain manufacturing activities. For its part, Pfizer will be operationally and financially responsible for research, development, manufacturing and commercialization activities for SB-525 and additional products.

“We believe SB-525 has the potential to be a best-in-class therapy that may provide patients with stable and durable levels of Factor VIII protein with a single administration treatment,” said Mikael Dolsten, president of worldwide research and development at Pfizer.

More than 150,000 people worldwide are believed to have the disorder, which is caused by a genetic mutation that results in insufficient activity of Factor VIII, a blood clotting protein.

Interview

Specialty Chemicals in a Shifting World
Adapting to Tariffs and Strengthening Regional Networks

Specialty Chemicals in a Shifting World

Jennifer Abril, President & CEO of SOCMA, discusses the impact of new tariffs and the importance of regional supply networks in the specialty chemical industry.

CHEManager Spotlight

Standardization and Harmonization of Digital Chemical and Pharmaceutical Logistics
Creating Interfaces

Standardization and Harmonization of Digital Chemical and Pharmaceutical Logistics

CHEManager Spotlight is an exclusive event tailored for practitioners and decision-makers in the chemical industry. This part of our event series delves into the latest trends and innovations in logistics to streamline your operations and drive efficiency.